Thermal remodeling of collagen (TCR) - MitraGen

Thermal remodeling of collagen (TRC) technologies have been known since at least 1871. In the early 1900’s scientists began exploring these technologies with scientific papers published.  One of the key paper describing the properties of TRC and it's clinical applications was published by Michael Wall, MD and associates.1

Collagen is the primary component of connective tissue and is the most abundant protein in mammals. The collagen fibril structure is formed by a series of collagen molecules that form and are held in tension as a triple strand helix. When heat is applied to the target tissue (using a specific protocol) the intramolecular hydrogen bonds rupture allowing the triple helices to unwind and shrink predictably.2

Key to MitraGen’s TMVR technology are:

  • The mitral valve annulus has a high collagen content
  • RF energy delivered through a series of electrodes will heat the tissue
  • When collagen is heated it will shrink and remodel the valve
  • Collagen shrinkage and valve remodeling is permanent


1. Thermal modification of collagen, Wall, MD, Journal of Shoulder Elbow Surgery, July/August 1999
2. Mechanism of Action, Peter Takacs, MD, Novasys, Inc. White Paper